Neurological Research

Dr. Barnard specializes in brain tumors, skull base tumors, spine tumors, strokes, and vascular and neuroendovascular surgery. Dr. Barnard is also an expert in pulsatile tinnitus, intracranial hypotension, cerebrospinal fluid leaks, idiopathic intracranial hypertension, and all areas of spine surgery.

Research

His research interests include the field of endovascular neuro-oncology, clinical trial development, and translational research for brain tumors. He has authored numerous peer-reviewed articles, book chapters, invited articles, and presented at multiple national meetings. He has been an ad hoc reviewer for multiple journals including; Cancer Research, Clinical Cancer Research, Molecular Cancer Therapeutics, Journal of Clinical Neuroscience, Journal of Neurological Surgery Part B: Skull Base, Operative Neurosurgery, and Journal of Neuro-oncology .

Selected bibliography

Schievink WI, Maya M, Barnard Z, Taché RB, Prasad RS, Wadhwa VS, Moser FG, Nuño M. The reversible impairment of behavioral variant frontotemporal brain sagging syndrome: Challenges and opportunities. Alzheimers Dement (N Y). 2022 Dec 18;8(1):e12367. doi: 10.1002/trc2.12367. PMID: 36544987; PMCID: PMC9760785.
La Dine AK, Fatima N, Barnard ZR, Slattery WH, Lekovic GP. Malignant progression of cerebellopontine angle solitary fibrous tumors following radiation: illustrative case. J Neurosurg Case Lessons. 2022 Mar 21;3(12):CASE21646. doi: 10.3171/CASE21646. PMID: 36273870; PMCID: PMC9379674.
Fatima N, La Dine AK, Barnard ZR, Ko K, Peng K, Slattery WH, Lekovic GP. Safety and Efficacy of Hypofractionated Stereotactic Radiosurgery in Facial Nerve Schwannoma. Otol Neurotol. 2022 Sep 1;43(8):e841-e845. doi: 10.1097/MAO.0000000000003594. Epub 2022 Jul 28. PMID: 35900912.
Fatima N, La Dine A, Barnard ZR, Lekovic GP. Segmental spinal neurofibromatosis 1: a novel phenotype. Neurol Sci. 2022 Aug;43(8):5103-5105. doi: 10.1007/s10072-022-06139-z. Epub 2022 May 20. PMID: 35595873.
Fatima N, Barnard ZR, Maxwell AK, Muelleman TJ, Slattery WH, Mehta GU, Wagner W, Lekovic GP. The Role of Intra-Operative Duplex Ultrasonography Following Translabyrinthine Approach for Vestibular Schwannoma. Front Surg. 2022 Apr 28;9:853704. doi: 10.3389/fsurg.2022.853704. PMID: 35574538; PMCID: PMC9096022.
Fatima N, Maxwell AK, La Dine A, Barnard ZR, Mehta GU, Wilkinson EP, Brackmann DE, Slattery WH, Lekovic GP. Predictors of hearing functional outcome following surgery for cerebellopontine angle meningioma. J Neurooncol. 2022 Mar;157(1):165-176. doi: 10.1007/s11060-022-03958-0. Epub 2022 Feb 3. PMID: 35113287.
Chan JL, Quintero-Consuegra MD, Babadjouni RM, Chang D, Barnard ZR, Martin NA, Ziv K, Van de Wiele BM, Gonzalez NR. Encephaloduroarteriosynangiosis Operative Technique and Intraoperative Anesthesia Management: Treatment From Both Sides of the Curtain. Oper Neurosurg (Hagerstown). 2022 Jan 1;22(1):20-27. doi: 10.1227/ONS.0000000000000009. PMID: 34982901.
Lekovic GP, Barnard ZR, Master A, Mehta GU, Maya MM, Wilkinson EP. Role of cerebral digital subtraction angiography in the evaluation of pulse synchronous tinnitus. J Otol. 2021 Oct;16(4):225-230. doi: 10.1016/j.joto.2021.03.002. Epub 2021 Apr 5. PMID: 34548868; PMCID: PMC8438631.
Maxwell AK, Muelleman T, Barnard Z, Slattery WH 3rd, Mehta GU, Lekovic GP. Clinical Significance of Middle Cerebellar Peduncle Ischemia After Translabyrinthine Vestibular Schwannoma Resection. Otol Neurotol. 2021 Aug 1;42(7):e930-e935. doi: 10.1097/MAO.0000000000003152. PMID: 33900231.
Noonan KY, Rock J, Barnard Z, Lekovic GP, Brackmann DE, Wilkinson EP. Bilateral Auditory Brainstem Implants in Patients With Neurofibromatosis 2. Otolaryngol Head Neck Surg [Internet] 2020 [cited 2021 Jan 29];194599820977420.
Christopher LH, Noonan K, Barnard Z, et al. Auditory Brainstem Implant in Adult Patient With Cochlear Ossification From Otosclerosis. Otol Neurotol [Internet] 2021 [cited 2021 Jan 29];42(2):e114–6.
Muelleman TJ, Alonso J, Barnard ZR, Maxwell AK, Mahboubi H, Stefan M, Lekovic GP, Slattery WH, Brackmann DE. Hypercoagulability in vestibular schwannoma surgery. Otology and Neurotology. 2020. Barnard ZR, Alexander MJ. Device profile of the Wingspan Stent System for the treatment of intracranial atherosclerotic disease: overview of its safety and efficacy. Expert Rev Med Devices 1–5 (2020). doi:10.1080/17434440.2020.1732813
Maxwell AK, Mehta GU, Muelleman T, Barnard ZR, Hartwick T, Brackmann DE, Lekovic GP. Hypo- fractionated robotic stereotactic radiosurgery for vagal paragangliomas: A novel treatment strategy for cranial nerve preservation. Otolaryngology- Head and Neck Surgery. Vol 162. No. 6. pp. 897-904. 2020.
Barnard ZR, Alexander MJ. Update in the treatment of intracranial atherosclerotic disease Stroke and Vascular Neurology 2019;svn-2019-000279. doi: 10.1136/svn-2019-000279.
Barnard ZR, Lekovic GP, Wilkinson EP, Peng KA. Vestibular nerve section via retrolabyrinthine craniotomy. Oper Tech Otolaryngol Neck Surg 30:212–216, 2019.
Lekovic GP, Batra A, Barnard ZR, Wilkinson EP, Balena R, Palejwala S, et al. Growth hormone- secreting pituitary macroadenoma presenting concurrently with non-Hodgkin’s lymphoma and responding to doxorubicin treatment: case report and review of the literature. Acta Neurochir (Wien). 2018.
Schievink WI, Maya MM, Barnard ZR, Moser FG, Jean-Pierre S, Waxman AD, et al: Behavioral Variant Frontotemporal Dementia as a Serious Complication of Spontaneous Intracranial Hypotension. Oper Neurosurg (Hagerstown, Md) 15:2018
Ko A, Harada MY, Barmparas G, Smith EJT, Birch K, Barnard ZR, et al. Limit Crystalloid Resuscitation after Traumatic Brain Injury. Am Surg. 2017;83(12):1447-52. PubMed PMID: 29336770.
Barnard ZR, Drazin D, Bannykh SI, Rudnick JD, Chu RM. Adult Brainstem Glioblastoma Multiforme: Long-term Survivor. Cureus. 2015;7(12):e434. doi: 10.7759/cureus.434. PubMed PMID: 26848423; PubMed Central PMCID: PMCPMC4727952.
Shweikeh F, Amadio JP, Arnell M, Barnard ZR, Kim TT, Johnson JP, Drazin D. Robotics and the spine: a review of current and ongoing applications. Neurosurg Focus. 2014 Mar;36(3):E10. doi: 10.3171/2014.1.FOCUS13526. Review.
Barnard Z, Wakimoto H, Zaupa C, Patel AP, Klehm J, Martuza RL, Rabkin SD, Curry WT. Expression of FMS-like Tyrosine Kinase 3 Ligand by Oncolytic Herpes Simplex Virus Type I Prolongs Survival in Mice Bearing Established Syngeneic Intracranial Malignant Glioma. Neurosurgery. 2012;71(3):741-8.
Agarwalla P, Barnard Z, Fecci P, Dranoff G, Curry WT, Jr. Sequential immunotherapy by vaccination with GM-CSF-expressing glioma cells and CTLA-4 blockade effectively treats established murine intracranial tumors. J Immunother. 2012;35(5):385-9.
Wakimoto H, Mohapatra G, Kanai R, Curry WT, Jr., Yip S, Nitta M, Patel AP, Barnard ZR, Stemmer- Rachamimov AO, Louis DN, Martuza RL, Rabkin SD. Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells. Neuro Oncol2011 Nov 7.
Walcott BP, Cvetanovich GL, Barnard ZR, Nahed BV, Kahle KT, Curry WT. Surgical treatment and outcomes of metastatic breast cancer to the spine. J Clin Neurosci2011 Oct;18(10):1336-9.
Kahle KT, Walcott BP, Nahed BV, Barnard ZR, Lo EH, Buonanno FS, Venna N, Ning M. Cerebral edema and a transtentorial brain herniation syndrome associated with pandemic swine influenza A (H1N1) virus infection. J Clin Neurosci2011 Jul 8.
Barnard ZR, Agarwalla PK, Jeyaretna DS, Farrell CJ, Gerstner ER, Tian D, Curry WT, Jr. Sporadic primary malignant intracerebral nerve sheath tumors: case report and literature review. J Neurooncol2011 Feb 15.
Barnard ZR, Walcott BP, Kahle KT, Nahed BV, Coumans JV. Hyponatremia associated with Ipilimumab- induced hypophysitis. Med Oncol2011 Jan 25.
Farrell CJ, Zaupa C, Barnard Z, Maley J, Martuza RL, Rabkin SD. Combination immunotherapy for tumors via sequential intratumoral injections of oncolytic herpes simplex virus 1 and immature dendritic cells. Clin Cancer Res 14:7711-7716, 2008

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